Ukraine came under a massive Russian missile and drone attack early Monday, with waves of explosions echoing through the capital, Kyiv, as air raids killed at least five people across the country.

Among the targets hit in the sustained barrage was the historic Dormition Cathedral within the Kyiv Pechersk Lavra, one of Ukraine’s most significant religious sites, as well as residential buildings across the city.

Footage from the Pechersk Lavra, a UNESCO World Heritage site, showed towering flames licking up toward its domes. Six people were reported injured.

"[T]he roof of one of the holiest places in the Christian world – the Dormition Cathedral of the Kyiv Pechersk Lavra – is burning," Metropolitan Epiphanius, head of the Orthodox Church of Ukraine, wrote on X.

Yulia Svyrydenko, the prime minister, posted a picture of the monastery building in flames and wrote: "A brutal assault on our people and our heritage. This is the true face of Russia’s Orthodox values."

"We ask for prayers for the salvation of the shrine from destruction. Another Russian crime against humanity, against history, against Christianity."

Damage was reported at 16 locations across the capital amid the sound of interceptor launches and explosions that shook windows in the city center.

"New launches targeting the capital keep being recorded," said Tymur Tkachenko, head of Kyiv’s military administration, urging people to remain in shelters as at least 10 people were reported injured.

The attacks across Ukraine came after Russian President Vladimir Putin warned that Moscow would target Ukraine with "systemic" strikes, and amid evidence of mounting battlefield setbacks for Russia.